I have read something over the internet that overusing the hands on a non-ergonomic keyboard may cause carpal tunnel. This surely raises concerns with my hands after intensively playing Ninja Gaiden last night.
Referring to this section of the carpal tunnel article, however, the causes of carpal tunnel syndrome (CTS) have not yet been found. Any condition that lessens the amount of space in the carpal tunnel can compress the median nerve in the tunnel, hence resulting in CTS. Some researchers believe that overuse of the wrist may be a cause of CTS. But this is not accepted by all physicians.
Since the correlation of repetitive strain injuries and carpal tunnel syndrome has not been established, it seems to me it would be OK to play some more Ninja Gaiden. Just have to get plenty of rest before the boss fight at the end of each chapter.
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